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EAST1 toxin: An enigmatic molecule associated with sporadic episodes of diarrhea in humans and animals

23 Apr 2019

Abstract excerpt

EAST1 is produced by a subset of enteroaggregative Escherichia coli strains. This toxin is a 38-amino acid peptide of 4100 Da. It shares 50% homology with the enterotoxic domain of STa and interacts with the same receptor. The mechanism of action of EAST1is proposed to be identical to that of STa eliciting a cGMP increase. EAST1 is associated with diarrheal disease in Man and various animal species including...

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PMID: 31016564
DOI: 10.1007/s12275-019-8651-4

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