Exosomes from N‐Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non‐N‐Myc amplified cells: implications of intra‐tumour heterogeneity

Abstract excerpt

ABSTRACT Neuroblastoma accounts for 15% of childhood cancer mortality. Amplification of the oncogene N‐Myc is a well‐established poor prognostic marker for neuroblastoma. Whilst N‐Myc amplification status strongly correlates with higher tumour aggression and resistance to treatment, the role of N‐Myc in the aggressiveness of the disease is poorly understood. Exosomes are released by many cell types including...

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