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Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk

11 Apr 2019

Abstract excerpt

Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high‐ and low‐penetrance genes have been implicated in PanC, their roles in carcinogenesis remain only partially elucidated. Because the nuclear factor erythroid2‐related factor2 (NRF2) signaling pathway is involved in human cancers, we hypothesize that genetic...

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PMID: 30972876
DOI: 10.1111/cas.14017

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