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Article

The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome

27 Mar 2019

Abstract excerpt

Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for...

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Identifiers

PMID: 30972300
DOI: 10.3389/fonc.2019.00192

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The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic SyndromePMID 30972300Read ↗

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