Article
Follicular lymphoma patients with KIR2DL2 and KIR3DL1 and their ligands (HLA-C1 and HLA-Bw4) show improved outcome when receiving rituximab.
Journal for immunotherapy of cancer - 12 Mar 2019
Erbe Amy K, Wang Wei, Carmichael Lakeesha, Hoefges Anna, Grzywacz Bartosz, Reville Patrick K, Ranheim Erik A, Hank Jacquelyn A, Kim KyungMann, Seo Songwon, Mendonca Eneida A, Song Yiqiang, Kenkre Vaishalee P, Hong Fangxin, Gascoyne Randy D, Paietta Elisabeth, Horning Sandra J, Miller Jeffrey S, Kahl Brad, Sondel Paul M
Abstract excerpt
BACKGROUND: The ECOG-ACRIN Cancer Research Group evaluated rituximab treatment schedules for patients with newly-diagnosed low-tumor-burden follicular-lymphoma (FL). All patients received 4-weekly rituximab treatments as induction therapy. Clinically-responding patients were randomized to receive rituximab every 13 weeks ("maintenance") vs. no additional rituximab until progression ("non-maintenance"). Based on...
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