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Article

The ovarian germinal reserve and apoptosis-related proteins in the infant and adolescent human ovary

11 Mar 2019

Abstract excerpt

BACKGROUND: Normal pubertal ovary displays all stages of follicular development and a biased BAX/BCL2 protein ratio in favor of pro-apoptotic BAX protein comparable to the adult ovary. However, adolescents suffering malignant extra-gonadal disease show a limited follicle development after cytotoxic drug treatment and a reduced capacity of in vitro follicle growth. We evaluated the expression of pro- and...

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PMID: 30857552
DOI: 10.1186/s13048-019-0496-2

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