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A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer

7 Mar 2019

Abstract excerpt

Glioblastoma multiforme (GBM; grade IV astrocytoma) is the most prevalent and aggressive form of primary brain cancer. A subpopulation of multipotent cells termed GBM cancer stem cells (CSCs) play a critical role in tumor initiation, tumor maintenance, metastasis, drug resistance, and recurrence following surgery. Here we report the identification of a small molecule, termed RIPGBM, from a cell-based chemical...

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PMID: 30846550
DOI: 10.1073/pnas.1816626116

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