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Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci

5 Mar 2019

Abstract excerpt

Mouth ulcers are the most common ulcerative condition and encompass several clinical diagnoses, including recurrent aphthous stomatitis (RAS). Despite previous evidence for heritability, it is not clear which specific genetic loci are implicated in RAS. In this genome-wide association study (n = 461,106) heritability is estimated at 8.2% (95% CI: 6.4%, 9.9%). This study finds 97 variants which alter the odds of...

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PMID: 30837455
DOI: 10.1038/s41467-019-08923-6

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