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Article

The influence of BRCA2 mutation on localized prostate cancer.

Nature reviews. Urology - 1 May 2019

Taylor Renea A, Fraser Michael, Rebello Richard J, Boutros Paul C, Murphy Declan G, Bristow Robert G, Risbridger Gail P

Abstract excerpt

A key challenge in the management of localized prostate cancer is the identification of men with a high likelihood of progression to an advanced, incurable stage. Patients who harbour germline BRCA2 mutations have worse clinical outcomes than noncarriers when treated with surgery or radiotherapy. Insights from different disciplines have improved our understanding of why patients with BRCA2-mutant tumours have a...

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PMID: 30808988
DOI: 10.1038/s41585-019-0164-8

Genes

BRCA2

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