Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Messenger RNA therapy for rare genetic metabolic diseases

22 Feb 2019

Abstract excerpt

Decades of intense research in molecular biology and biochemistry are fructifying in the emergence of therapeutic messenger RNAs (mRNA) as a new class of drugs. Synthetic mRNAs can be sequence optimised to improve translatability into proteins, as well as chemically modified to reduce immunogenicity and increase chemical stability using naturally occurring uridine modifications. These structural improvements,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Folate and B Vitamins Research
Share to Metabolism and Genetic Disorders
Share to Porphyrin Metabolism and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30796097
DOI: 10.1136/gutjnl-2019-318269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Messenger RNA therapy for rare genetic metabolic diseasesPMID 30796097Read ↗

Delivering the Message: Translating mRNA Therapy for Liver Inherited Metabolic DiseasesSemantic proximity Read ↗

RNA nanomedicine in liver diseasesSemantic proximity Read ↗

mRNA and gene editing: Late breaking therapies in liver diseasesSemantic proximity Read ↗

mRNA-Based Approaches to Treating Liver DiseasesSemantic proximity Read ↗

Gene therapy for urea cycle defects: An update from historical perspectives to future prospectsSemantic proximity Read ↗

Advances in RNA Therapeutics: Classes, Innovations and Clinical ApplicationsSemantic proximity Read ↗

The Evolution of Gene Therapy in the Treatment of Metabolic Liver Diseases.Semantic proximity Read ↗

Emerging mRNA Technology for Liver Disease TherapySemantic proximity Read ↗

Genetic-Based Approaches to Inherited Metabolic Liver DiseasesSemantic proximity Read ↗

Liver‐directed gene therapy for inherited metabolic diseasesSemantic proximity Read ↗

tRNA therapeutics for genetic diseases.Semantic proximity Read ↗

Enzyme Replacement Therapy for Genetic Disorders Associated with Enzyme DeficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.