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Article

Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome

13 Feb 2019

Abstract excerpt

BACKGROUND: Studies of the cystic fibrosis (CF) lung microbiome have consistently shown that lung function decline is associated with decreased microbial diversity due to the dominance of opportunistic pathogens. However, how this phenomenon is reflected in the metabolites and chemical environment of lung secretions remains poorly understood. METHODS: Here we investigated the microbial and molecular composition...

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PMID: 30760325
DOI: 10.1186/s40168-019-0636-3

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