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Article

Lysosomal trapping of palbociclib and its functional implications

28 Jan 2019

Abstract excerpt

Palbociclib is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) approved for the treatment of some cancers. The main mechanism of action of palbociclib is to induce cell cycle arrest and senescence on responsive cells. Here, we report that palbociclib concentrates in intracellular acidic vesicles, where it can be readily observed due to its intrinsic fluorescence, and it is released from these...

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PMID: 30692638
DOI: 10.1038/s41388-019-0695-8

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