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Article

GATA6 suppresses migration and metastasis by regulating the miR-520b/CREB1 axis in gastric cancer

15 Jan 2019

Abstract excerpt

Transcription factors (TFs) and microRNAs (miRNAs) are tightly linked to each other in tumor development and progression, but their interactions in gastric cancer (GC) metastasis remain elusive. Here we report a novel suppressive role of GATA6 in inhibiting GC metastasis by transactivating miR-520b. We found that GATA6 expression was significantly downregulated in metastatic GC cells and tissues and that its...

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PMID: 30674866
DOI: 10.1038/s41419-018-1270-x

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