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Article

Fibroblast growth factor-5 promotes spermatogonial stem cell proliferation via ERK and AKT activation

22 Jan 2019

Abstract excerpt

BACKGROUND: Sertoli cells are the most important somatic cells contributing to the microenvironment (named niche) for spermatogonial stem cells (SSCs). They produce amounts of crucial growth factors and structure proteins that play essential roles in the complex processes of male SSCs survival, proliferation, and differentiation. It has been suggested that Sertoli cell abnormalities could result in...

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PMID: 30670081
DOI: 10.1186/s13287-019-1139-7

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