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Article

High frequencies of circulating memory T cells specific for calreticulin exon 9 mutations in healthy individuals

17 Jan 2019

Abstract excerpt

Mutations in exon 9 of the calreticulin gene (CALR) frequently occur in patients with chronic myeloproliferative neoplasms (MPN). Patients exhibit spontaneous cellular immune responses to epitopes derived from the mutant CALR C-terminus, and CALR-mutant-specific T cells recognize autologous CALR-mutant malignant cells. This study investigated whether CALR-mutant-specific T cells occur naturally in CALRwt...

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PMID: 30655510
DOI: 10.1038/s41408-018-0166-4

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