Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway

1 Dec 2018

Abstract excerpt

BACKGROUND: MLH1 plays a critical role in maintaining the fidelity of DNA replication, and defects in human MLH1 have been reported. However, the role of MLH1 in endometrial carcinoma has not been fully investigated. Therefore, we aimed to study the role of MLH1 in the sensitivity of human endometrial carcinoma cells to cisplatin. METHODS: In this study, we detected the expression of MLH1 in Ishikawa and RL95-2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Myeloid Leukemia Treatments
Share to Genetic factors in colorectal cancer
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30594176
DOI: 10.1186/s12885-018-5218-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathwayPMID 30594176Read ↗

Depleted-MLH1 Expression Predicts Prognosis and Immunotherapeutic Efficacy in Uterine Corpus Endometrial Cancer: An In Silico ApproachSemantic proximity Read ↗

Lynch syndrome-associated endometrial carcinoma with MLH1 germline mutation and MLH1 promoter hypermethylation: a case report and literature reviewSemantic proximity Read ↗

LRH1 promotes tumor cell proliferation and migration, and is correlated with poor prognosis in ovarian cancerSemantic proximity Read ↗

PGK1 facilities cisplatin chemoresistance by triggering HSP90/ERK pathway mediated DNA repair and methylation in endometrial endometrioid adenocarcinomaSemantic proximity Read ↗

Differential outcomes and immune checkpoint inhibitor response among endometrial cancer patients with MLH1 hypermethylation versus MLH1 "Lynch-like" mismatch repair gene mutation.Semantic proximity Read ↗

The relationship between the PD-1/PD-L1 pathway and DNA mismatch repair in cervical cancer and its clinical significanceSemantic proximity Read ↗

HMGB1 assists in overcoming cisplatin resistance in chemoresistant human ovarian cancer cellsSemantic proximity Read ↗

Knockdown of the stem cell marker Musashi-1 inhibits endometrial cancer growth and sensitizes cells to radiationSemantic proximity Read ↗

ATM, BLM, and CDH1 gene co-mutations in a high-grade endometrial stromal sarcoma patient with multiple abdominal cavity metastases: a case report and literature review.Semantic proximity Read ↗

The Prognostic Impact of MLH1 Promoter Hypermethylation in Stage I-II Endometrial Cancer Treated With Adjuvant Radiation Therapy: A Multi-Institutional Retrospective Study.Semantic proximity Read ↗

MLH1 promoter hypermethylation predicts poorer prognosis in mismatch repair deficiency endometrial carcinomasSemantic proximity Read ↗

HP1γ Sensitizes Cervical Cancer Cells to Cisplatin through the Suppression of UBE2L3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.