Article
Adapting clinical trial design to maintain meaningful outcomes during a multicenter asthma trial in the precision medicine era.
Contemporary clinical trials - 1 Feb 2019
Sorkness Christine A, King Tonya S, Dyer Anne-Marie, Chinchilli Vernon M, Mauger David T, Krishnan Jerry A, Blake Kathryn, Castro Mario, Covar Ronina, Israel Elliot, Kraft Monica, Lang Jason E, Lugogo Njira, Peters Stephen P, Wechsler Michael E, Wenzel Sally E, Lazarus Stephen C
Abstract excerpt
Precision medicine is expected to impact the care of people with asthma, given its high disease prevalence, heterogeneity of pathophysiologic mechanisms, and consequent clinical phenotypes. A novel phenotype-stratified clinical trial conducted by the NHLBI AsthmaNet Consortium, titled Steroids in Eosinophil Negative Asthma (SIENA), was a randomized, multicenter, clinical trial that prospectively stratified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.