BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2.

doi:10.1371/journal.pgen.1007752

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Article

BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2.

PLoS genetics - 1 Dec 2018

Cline Melissa S, Liao Rachel G, Parsons Michael T, Paten Benedict, Alquaddoomi Faisal, Antoniou Antonis, Baxter Samantha, Brody Larry, Cook-Deegan Robert, Coffin Amy, Couch Fergus J, Craft Brian, Currie Robert, Dlott Chloe C, Dolman Lena, den Dunnen Johan T, Dyke Stephanie O M, Domchek Susan M, Easton Douglas, Fischmann Zachary, Foulkes William D, Garber Judy, Goldgar David, Goldman Mary J, Goodhand Peter, Harrison Steven, Haussler David, Kato Kazuto, Knoppers Bartha, Markello Charles, Nussbaum Robert, Offit Kenneth, Plon Sharon E, Rashbass Jem, Rehm Heidi L, Robson Mark, Rubinstein Wendy S, Stoppa-Lyonnet Dominique, Tavtigian Sean, Thorogood Adrian, Zhang Can, Zimmermann Marc, Burn John, Chanock Stephen, Rätsch Gunnar, Spurdle Amanda B

Abstract excerpt

The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly collaborative research activities. Its goal is to generate an informed and current understanding of the impact of genetic variation on cancer risk across the iconic cancer predisposition genes, BRCA1 and BRCA2. Initially, reported variants...

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Identifiers

PMID: 30586411
DOI: 10.1371/journal.pgen.1007752
PMCID: PMC6324924

Genes

BRCA1
BRCA2

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