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Article

The genetics and clinical characteristics of children morphologically diagnosed as acute promyelocytic leukemia.

Leukemia - 1 Jun 2019

Zhao Jie, Liang Jian-Wei, Xue Hui-Liang, Shen Shu-Hong, Chen Jing, Tang Yan-Jing, Yu Li-Sha, Liang Huan-Huan, Gu Long-Jun, Tang Jing-Yan, Li Ben-Shang

Abstract excerpt

Acute promyelocytic leukemia (APL) is characterized by t(15;17)(q22;q21), resulting in a PML-RARA fusion that is the master driver of APL. A few cases that cannot be identified with PML-RARA by using conventional methods (karyotype analysis, FISH, and RT-PCR) involve abnormal promyelocytes that are fully in accordance with APL in morphology, cytochemistry, and immunophenotype. To explore the mechanisms involved...

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Source

Identifiers

PMID: 30575821
DOI: 10.1038/s41375-018-0338-z

Genes

RARA
WT1
NPM1
PML
FLT3
NRAS
RARB
RARG
ARID1A
CCDC28A
CPSF6
KMT2A
NSD1
RAB21
TBC1D15
TBL1XR1
TP53
USP9X

Provenance

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