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Article

PARP inhibitors in ovarian cancer

4 Dec 2018

Abstract excerpt

Poly-ADP-ribosepolymerase inhibitors (PARPis) are the most active and interesting therapies approved for the treatment of epithelial ovarian cancer. They have changed the clinical management of a disease characterized, in almost half of cases, by extreme genetic complexity and alteration of DNA damage repair pathways, particularly homologous recombination (HR) deficiency. In this review, we provide an updated...

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PMID: 30543930
DOI: 10.1016/j.ctrv.2018.12.002

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