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Mutation profile of FLNC gene and its prognostic relevance in patients with hypertrophic cardiomyopathy

1 Nov 2018

Abstract excerpt

BACKGROUND: Filamin C (FLNC) mutation was reported as a cause of HCM, with a high probability of sudden cardiac death. However, the mutation profile of FLNC, and its relationship with phenotypic expression in HCM, remains to be elucidated. METHODS: In this study, FLNC gene was sequenced in 540 HCM patients and 307 healthy controls. RESULTS: We found that 39 (7.2%) patients carried FLNC mutations, with a similar...

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PMID: 30411535
DOI: 10.1002/mgg3.488

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