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Article

Spindle pole body component 25 regulates stemness of prostate cancer cells

8 Nov 2018

Abstract excerpt

Spindle pole body component 25 (SPC25) is a component of NDC80 complex that controls spindle assembly checkpoint in the microtubule-binding domain of kinetochores. We recently showed that SPC25 is required for prostate cancer (PrC) cell proliferation and cell cycle progression, and here we investigated whether SPC25 may be a Cancer stem cell (CSC) marker in PrC. We found that the levels of SPC25 were higher in...

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PMID: 30408771
DOI: 10.18632/aging.101631

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