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Article

Lacosamide for SCN2A ‐related intractable neonatal and infantile seizures

1 Oct 2018

Abstract excerpt

Voltage-gated sodium channel alpha subunit 2 (SCN2A) gene mutations are associated with neonatal seizures and a wide range of epilepsy syndromes. Previous reports suggest that traditional sodium channel blockers (SCBs) such as phenytoin, carbamazepine, and lamotrigine have a beneficial effect on SCN2A-related neonatal seizures, as they counteract the gain-of-function effect of mutated Nav1.2 channels....

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PMID: 30361185
DOI: 10.1684/epd.2018.1001

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