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Nicotine Promotes Human Papillomavirus (HPV)-Immortalized Cervical Epithelial Cells (H8) Proliferation by Activating RPS27a-Mdm2-P53 Pathway In Vitro

28 Sept 2018

Abstract excerpt

HPV infection is the main risk factor for cervical cancer, but it is still an insufficient event for the development of this cancer. It has demonstrated that nicotine plays an important role in cervical carcinogenesis. However, the effects and mechanisms of nicotine stimulation on precancerous lesions of cervical cancer are not clear. In this study, it showed that nicotine significantly promoted H8 cells...

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PMID: 30272249
DOI: 10.1093/toxsci/kfy246

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