Tolerating the Unwelcome Guest; How the Host Withstands Persistent Mycobacterium tuberculosis

Abstract excerpt

Our understanding of the host response to infections has historically focused on "resistance" mechanisms that directly control pathogen replication. However, both pathogen effectors and antimicrobial immune pathways have the capacity to damage host tissue, and the ability to tolerate these insults can also be critical for host survival. These "tolerance" mechanisms may be equally as important as resistance to...

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