Article
Deconstructing and targeting the genomic architecture of human neurodegeneration.
Nature neuroscience - 1 Oct 2018
De Jager Philip L, Yang Hyun-Sik, Bennett David A
Abstract excerpt
The field of neurodegenerative disease research has seen tremendous advances over the last two decades as new technologies and analytic methods have enabled well-powered human genomic studies. Driven first by genetic studies and more recently by transcriptomic and epigenomic studies of proper size, we have uncovered a large repertoire of loci, genes, and molecular features that are implicated in discrete,...
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