Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long noncoding RNA LINC00261 induces chemosensitization to 5‐fluorouracil by mediating methylation‐dependent repression of DPYD in human esophageal cancer

18 Sept 2018

Abstract excerpt

Approximately 85% of a single administered dose of 5-fluorouracil (5-FU) will be degraded by dihydropyrimidine dehydrogenase (DYPD). Studies have highlighted a link between the complete or partial loss of DYPD function and clinical responses to 5-FU; however, the underlying molecular basis of DPD deficiency remains poorly understood. Hence, the aim of the present study was to evaluate the prevailing hypothesis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Gastric Cancer Management and Outcomes
Share to Mycobacterium research and diagnosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30226808
DOI: 10.1096/fj.201800759r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Long noncoding RNA LINC00261 induces chemosensitization to 5‐fluorouracil by mediating methylation‐dependent repression of DPYD in human esophageal cancerPMID 30226808Read ↗

Aberrant Methylation of <b> <i>DPYD</i> </b> Promoter, <b> <i>DPYD</i> </b> Expression, and Cellular Sensitivity to 5-Fluorouracil in Cancer CellsSemantic proximity Read ↗

Downregulation of Linc00173 increases BCL2 mRNA stability via the miR-1275/PROCA1/ZFP36L2 axis and induces acquired cisplatin resistance of lung adenocarcinomaSemantic proximity Read ↗

Upregulated long-non-coding RNA DLEU2 exon 9 expression was an independent indicator of unfavorable overall survival in patients with esophageal adenocarcinomaSemantic proximity Read ↗

Long non-coding RNA NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of esophageal squamous cell carcinoma by promoting nuclear accumulation of β-cateninSemantic proximity Read ↗

Dihydropyrimidine dehydrogenase (DPD) expression is negatively regulated by certain microRNAs in human lung tissues.Semantic proximity Read ↗

CircRNA-DOPEY2 Enhances The Chemosensitivity of Esophageal Cancer Cells By Inhibiting CPEB4-Mediated Mcl-1 TranslationSemantic proximity Read ↗

Silence of long noncoding RNA UCA1 inhibits malignant proliferation and chemotherapy resistance to adriamycin in gastric cancerSemantic proximity Read ↗

THUMP domain containing 2 protein possibly induces resistance to cisplatin and 5-fluorouracil in in vitro human esophageal squamous cell carcinoma cells as revealed by transposon activation mutagenesis.Semantic proximity Read ↗

Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitorSemantic proximity Read ↗

miR-221 Mediates Chemoresistance of Esophageal Adenocarcinoma by Direct Targeting of DKK2 ExpressionSemantic proximity Read ↗

Hypermethylation of the DPYD promoter region is not a major predictor of severe toxicity in 5-fluorouracil based chemotherapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.