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Article

KRAS-specific Amino Acid Substitutions are Associated With Different Responses to Chemotherapy in Advanced Non-small-cell Lung Cancer.

Clinical lung cancer - 1 Nov 2018

Renaud Stéphane, Guerrera Francesco, Seitlinger Joseph, Reeb Jérémie, Voegeli Anne-Claire, Legrain Michèle, Mennecier Bertrand, Santelmo Nicola, Falcoz Pierre-Emmanuel, Quoix Elisabeth, Chenard Marie-Pierre, Weingertner Noëlle, Beau-Faller Michèle, Massard Gilbert

Abstract excerpt

BACKGROUND: Emerging data highlight different clinical behaviors according to KRAS amino acid substitutions (AASs) in patients with non-small-cell lung cancer (NSCLC). We aimed to evaluate whether different KRAS AASs were associated with different responses to chemotherapy. PATIENTS AND METHODS: We retrospectively reviewed data from 1190 patients with KRAS mutations who underwent first-line platinum-based...

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Identifiers

PMID: 30217639
DOI: 10.1016/j.cllc.2018.08.005

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