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Article

Progression of myocardial ischemia leads to unique changes in immediate-early gene expression in the spinal cord dorsal horn

14 Sept 2018

Abstract excerpt

The pathological consequences of ischemic heart disease involve signaling through the autonomic nervous system. Although early activation may serve to maintain hemodynamic stability, persistent aberrant sympathoexcitation contributes to the development of lethal arrhythmias and heart failure. We hypothesized that as the myocardium reacts and remodels to ischemic injury over time, there is an analogous sequence of...

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PMID: 30216122
DOI: 10.1152/ajpheart.00337.2018

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