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Article

Changes in biophysical characteristics of PFN1 due to mutation causing amyotrophic lateral sclerosis.

Metabolic brain disease - 1 Dec 2018

Nekouei Mina, Ghezellou Parviz, Aliahmadi Atousa, Arjmand Sareh, Kiaei Mahmoud, Ghassempour Alireza

Abstract excerpt

Single amino acid mutations in profilin 1 (PFN1) have been found to cause amyotrophic lateral sclerosis (ALS). Recently, we developed a mouse model for ALS using a PFN1 mutation (glycine 118 to valine, G118V), and we are now interested in understanding how PFN1 becomes toxically lethal with only one amino acid substitution. Therefore, we studied mutation-related changes in the PFN1 protein and hypothesized that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30203378
DOI: 10.1007/s11011-018-0305-4
PMCID: PMC6230493

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