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Article

Osimertinib With Ramucirumab in EGFR-mutated, T790M-positive Patients With Progression During EGFR-TKI Therapy: Phase Ib Study.

Clinical lung cancer - 1 Nov 2018

Akamatsu Hiroaki, Koh Yasuhiro, Ozawa Yuichi, Fujimoto Daichi, Hata Akito, Katakami Nobuyuki, Tomii Keisuke, Shimokawa Toshio, Yamamoto Nobuyuki

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) T790M mutation is the most frequent mechanism of resistance among patients with progression during EGFR-tyrosine kinase inhibitor (TKI) therapy. A third-generation EGFR-TKI, osimertinib, demonstrated durable efficacy with mild adverse events in a phase III trial and is considered a novel standard regimen. The tolerability of osimertinib monotherapy has allowed...

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PMID: 30197264
DOI: 10.1016/j.cllc.2018.08.001

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