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Article

Functional Characterization of Thyrostimulin in Amphioxus Suggests an Ancestral Origin of the TH Signaling Pathway

4 Sept 2018

Abstract excerpt

Thyrostimulin, consisting of GpA2 and GpB5 subunits, has been identified in amphioxus, but to date, little is known about the roles of GPA2/GPB5‒type hormone in this evolutionarily important animal. We showed here that amphioxus GpA2, GpB5, and TSH receptor (TSHR) represent the archetypes of vertebrate TSHα, TSHβ, and TSHR, respectively, and both gpa2 and gpb5 were coexpressed in the Hatschek pit, a homolog of...

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Identifiers

PMID: 30192937
DOI: 10.1210/en.2018-00550

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