Article
Unexpected finding of uniparental disomy mosaicism in term placentas: Is it a common feature in trisomic placentas?
Prenatal diagnosis - 1 Nov 2018
Van Opstal Diane, Diderich Karin E M, Joosten Marieke, Govaerts Lutgarde C P, Polak Joke, Boter Marjan, Saris Jasper J, Cheung Wai Yee, van Veen Stefanie, van de Helm Robert, Go Attie T J I, Knapen Maarten F C M, Papatsonis Dimitri N M, Dijkman Anneke, de Vries Femke, Galjaard Robert-Jan H, Hoefsloot Lies H, Srebniak Malgorzata I
Abstract excerpt
OBJECTIVE: Non-invasive prenatal testing (NIPT) detects placental chromosome aberrations. When amniocentesis reveals a normal karyotype, confined placental mosaicism (CPM) may be assumed. In order to confirm this, placental cytogenetic studies were performed. METHOD: NIPT was conducted in the course of the Dutch TRIDENT study. Placentas of 10 cases with NIPT results indicating an autosomal trisomy and showing a...
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