Article
Evolution of Brain Glucose Metabolic Abnormalities in Children With Epilepsy and SCN1A Gene Variants.
Journal of child neurology - 1 Nov 2018
Kumar Ananyaa, Juhász Csaba, Luat Aimee, Govil-Dalela Tuhina, Behen Michael E, Hicks Melissa A, Chugani Harry T
Abstract excerpt
Three children with drug-refractory epilepsy, normal magnetic resonance image (MRI), and a heterozygous SCN1A variant underwent 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography (FDG-PET) scanning between age 6 months and 1 year and then at age 3 years 6 months to 5 years 5 months. Regional FDG uptake values were compared to those measured in age- and gender-matched pseudo-controls. At baseline, the...
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