Article
Large-effect loci affect survival in Tasmanian devils (Sarcophilus harrisii) infected with a transmissible cancer.
Molecular ecology - 1 Nov 2018
Margres Mark J, Jones Menna E, Epstein Brendan, Kerlin Douglas H, Comte Sebastien, Fox Samantha, Fraik Alexandra K, Hendricks Sarah A, Huxtable Stewart, Lachish Shelly, Lazenby Billie, O'Rourke Sean M, Stahlke Amanda R, Wiench Cody G, Hamede Rodrigo, Schönfeld Barbara, McCallum Hamish, Miller Michael R, Hohenlohe Paul A, Storfer Andrew
Abstract excerpt
Identifying the genetic architecture of complex phenotypes is a central goal of modern biology, particularly for disease-related traits. Genome-wide association methods are a classical approach for identifying the genomic basis of variation in disease phenotypes, but such analyses are particularly challenging in natural populations due to sample size difficulties. Extensive mark-recapture data, strong linkage...
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