Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation.

doi:10.1021/acs.jmedchem.8b00705

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Article

Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation.

Journal of medicinal chemistry - 11 Oct 2018

Yang Xinglin, Chen Xiang-Jun, Yang Zimo, Xi Yi-Bo, Wang Liguo, Wu Yue, Yan Yong-Bin, Rao Yu

Abstract excerpt

We describe here the development of potent synthetic analogues of the naturally occurring triterpenoid lanosterol to reverse protein aggregation in cataracts. Lanosterol showed superiority to other scaffolds in terms of efficacy and generality in previous studies. Various modified lanosterol derivatives were synthesized via modification of the side chain, ring A, ring B, and ring C. Evaluation of these synthetic...

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PMID: 30153006
DOI: 10.1021/acs.jmedchem.8b00705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.