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Impacts of L1 Promoter Variation and L2 Clavulanate Susceptibility on Ticarcillin-Clavulanate Susceptibility of Stenotrophomonas maltophilia.

Antimicrobial agents and chemotherapy - 1 Nov 2018

Huang Hsin-Hui, Chen Peng-Ying, Hu Rouh-Mei, Lin Yi-Tsung, Li Li-Hua, Yang Tsuey-Ching

Abstract excerpt

Inducible expression of L1 and L2 β-lactamases is the principal mechanism responsible for β-lactam resistance in Stenotrophomonas maltophilia Ticarcillin-clavulanate (TIM) is one of the few effective β-lactams for S. maltophilia treatment. Clavulanate (CA) is a β-lactamase inhibitor that specifically targets class A, C, and D β-lactamases. In view of the presence of class B L1 β-lactamase, it is of interest to...

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Identifiers

PMID: 30150476
DOI: 10.1128/AAC.01222-18
PMCID: PMC6201090

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