Article
Proteomic analysis of clinical isolate of Stenotrophomonas maltophilia with blaNDM-1, blaL1 and blaL2 β-lactamase genes under imipenem treatment.
Journal of proteome research - 3 Aug 2012
Liu Wei, Zou Dayang, Wang Xuesong, Li XueLian, Zhu Li, Yin Zhitao, Yang Zhan, Wei Xiao, Han Li, Wang Yufei, Shao Changlin, Wang Simiao, He Xiang, Liu Dawei, Liu Feng, Wang Jie, Huang Liuyu, Yuan Jing
Abstract excerpt
The co-occurrence of L1 and AmpR-L2 with bla(NDM-1) gene with an upstream 250-bp promoter was detected in a clinical isolate of Stenotrophomonas maltophilia DCPS-01, which was resistant to all β-lactams and sensitive only to colistin and fluoroquinolones. To investigate expression of resistance genes and the molecular mechanisms of bacteria resistance to carbapenems, proteomic profiles of the isolate was...
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