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Generation of a human iPSC line from a patient with autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) caused by mutation in SACSIN gene.

Stem cell research - 1 Aug 2018

Arellano Candela Machuca, Vilches Angel, Clemente Eleonora, Pascual-Pascual Samuel Ignacio, Bolinches-Amorós Arantxa, Castro Ana Artero, Espinos Carmen, Rodriguez Marian Leon, Jendelova Pavla, Erceg Slaven

Abstract excerpt

The human iPSC cell line, ARS-FiPS4F1 (ESi063-A), derived from dermal fibroblast from the patient autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) caused by mutations on the gene SACSIN, was generated by non-integrative reprogramming technology using OCT3/4, SOX2, CMYC and KLF4 reprogramming factors. The pluripotency was assessed by immunocytochemistry and RT-PCR. Differentiation capacity was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30144656
DOI: 10.1016/j.scr.2018.07.012

Genes

KLF4
SOX2

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