Article
Rapamycin rescues BMP mediated midline craniosynostosis phenotype through reduction of mTOR signaling in a mouse model.
Genesis (New York, N.Y. : 2000) - 1 Jun 2018
Kramer Kaitrin, Yang Jingwen, Swanson W Benton, Hayano Satoru, Toda Masako, Pan Haichun, Kim Jin Koo, Krebsbach Paul H, Mishina Yuji
Abstract excerpt
Craniosynostosis is defined as congenital premature fusion of one or more cranial sutures. While the genetic basis for about 30% of cases is known, the causative genes for the diverse presentations of the remainder of cases are unknown. The recently discovered cranial suture stem cell population affords an opportunity to identify early signaling pathways that contribute to craniosynostosis. We previously...
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