Article
Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing.
Molecular psychiatry - 1 Sept 2020
Corominas Jordi, Klein Marieke, Zayats Tetyana, Rivero Olga, Ziegler Georg C, Pauper Marc, Neveling Kornelia, Poelmans Geert, Jansch Charline, Svirin Evgeniy, Geissler Julia, Weber Heike, Reif Andreas, Arias Vasquez Alejandro, Galesloot Tessel E, Kiemeney Lambertus A L M, Buitelaar Jan K, Ramos-Quiroga Josep-Antoni, Cormand Bru, Ribasés Marta, Hveem Kristian, Gabrielsen Maiken Elvestad, Hoffmann Per, Cichon Sven, Haavik Jan, Johansson Stefan, Jacob Christian P, Romanos Marcel, Franke Barbara, Lesch Klaus-Peter
Abstract excerpt
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with a complex genetic background, hampering identification of underlying genetic risk factors. We hypothesized that combining linkage analysis and whole-exome sequencing (WES) in multi-generation pedigrees with multiple affected individuals can point toward novel ADHD genes. Three families with multiple ADHD-affected members...
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