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Fetal undernutrition, placental insufficiency, and pancreatic β-cell development programming in utero

15 Aug 2018

Abstract excerpt

The prevalence of obesity and type 2 (T2D) diabetes is a major health concern in the United States and around the world. T2D is a complex disease characterized by pancreatic β-cell failure in association with obesity and insulin resistance in peripheral tissues. Although several genes associated with T2D have been identified, it is speculated that genetic variants account for only <10% of the risk for this...

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PMID: 30110175
DOI: 10.1152/ajpregu.00072.2018

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