Article
SCARB1 rs5888 gene polymorphisms in coronary heart disease: A systematic review and a meta-analysis.
Gene - 15 Dec 2018
Ma Ruchao, Zhu Xiaoyun, Yan Bo
Abstract excerpt
BACKGROUND: Studies have suggested that high-density lipoprotein (HDL) stimulates scavenger receptor class B type 1 (SR-B1) to promote hepatic uptake of cholesterol. SR-B1 is encoded by scavenger receptor class B member 1 (SCARB1) gene in human. A rare mutation in SCARB1 gene has been associated with coronary heart disease (CHD). A polymorphism rs5888 of SCARB1 gene has been linked to CHD risk in humans....
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