Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical characteristics, genetic spectrum and therapeutic effects of 51 male patients with idiopathic hypogonadotropic hypogonadism from southern China.

Orphanet journal of rare diseases - 12 Nov 2025

Sheng Huiying, Liang Cuili, Cheng Jing, Liu Huazhen, Mao Xiaojian, Li Xiuzhen, Li Duan, Lu Zhikun, Cai Yanna, Su Xueying, Zhang Liyu, Fu Wen, Hu Jinhua, Jia Wei, Liu Guochang, Zhang Wen, Liu Li, Lin Yunting

Abstract excerpt

BACKGROUND: Idiopathic hypogonadotropic hypogonadism (IHH) is a set of rare diseases characterized by abnormal sexual development with clinical heterogeneity and genotypic complexity. This study aims to investigate the phenotypic and genotypic characteristics of male IHH in southern China, and evaluate the therapeutic effects of current treatments. METHODS: Fifty-one male IHH patients from southern China were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to China
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix Proteins

Share to Hypogonadism

Share to Luteinizing Hormone

Share to Nerve Tissue Proteins

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Testosterone

Source

Open in PubMed Open full text

Identifiers

PMID: 41225491
DOI: 10.1186/s13023-025-04050-2
PMCID: PMC12613655

Genes

IHH
AMH
ANOS1
CHD7
FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical characteristics, genetic spectrum and therapeutic effects of 51 male patients with idiopathic hypogonadotropic hypogonadism from southern China.PMID 41225491Read ↗

Clinical and molecular features of idiopathic hypogonadotropic hypogonadism in Taiwan: A single center experienceSemantic proximity Read ↗

Genetic Profiles and Three-year Follow-up Study of Chinese Males With Congenital Hypogonadotropic Hypogonadism.Semantic proximity Read ↗

Mutation profiles and clinical characteristics of Chinese males with isolated hypogonadotropic hypogonadism.Semantic proximity Read ↗

Clinical characteristics and molecular genetic analysis of a cohort with idiopathic congenital hypogonadism.Semantic proximity Read ↗

Genotypic and phenotypic spectra of FGFR1, FGF8, and FGF17 mutations in a Chinese cohort with idiopathic hypogonadotropic hypogonadism.Semantic proximity Read ↗

Clinical, hormonal, and genetic characteristics of 25 Chinese patients with idiopathic hypogonadotropic hypogonadism.Semantic proximity Read ↗

Clinical manifestations and spermatogenesis outcomes in Chinese patients with congenital hypogonadotropic hypogonadism caused by inherited or de novo FGFR1 mutations.Semantic proximity Read ↗

[Analysis of CHD7 gene variants in 22 patients with idiopathic hypogonadotropic hypogonadism].Semantic proximity Read ↗

Correlations Among Genotype and Outcome in Chinese Male Patients With Congenital Hypogonadotropic Hypogonadism Under HCG Treatment.Semantic proximity Read ↗

Regional genotypic variations in normosmic congenital hypogonadotropic hypogonadism: our experience and systematic review.Semantic proximity Read ↗

[Genetic variants analysis of 17 female patients with idiopathic hypogonadotropic hypogonadism].Semantic proximity Read ↗

[Clinical feature and genetic analysis of a patient with Idiopathic hypogonadotropic hypogonadism due to a novel variant of CHD7 gene].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.