Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Everolimus in infants with tuberous sclerosis complex-related West syndrome: First results from a single-center prospective observational study.

Epilepsia - 1 Sept 2018

Samueli Sharon, Dressler Anastasia, Gröppel Gudrun, Scholl Theresa, Feucht Martha

Abstract excerpt

Tuberous sclerosis complex (TSC) is the most common cause of West syndrome (WS). Currently available treatment options are ineffective in the majority of affected infants and/or associated with potential serious side effects. Based on the assumption that mTOR overactivation results in increased neuroexcitability in TSC, mTOR inhibitors have been studied as antiseizure therapy. As a result, everolimus recently...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electroencephalography
Share to Everolimus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunosuppressive Agents

Share to Infant

Share to Spasms, Infantile

Share to Treatment Outcome

Share to Tuberous Sclerosis

Share to Tuberous Sclerosis Complex 2 Protein

Source

Identifiers

PMID: 30098008
DOI: 10.1111/epi.14529

Genes

TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Everolimus in infants with tuberous sclerosis complex-related West syndrome: First results from a single-center prospective observational study.PMID 30098008Read ↗

Effect of mTOR Inhibitors in Epilepsy Treatment in Children with Tuberous Sclerosis Complex Under 2 Years of AgeSemantic proximity Read ↗

Peri-ictal EEG in infants with PRRT2-related self-limited infantile epilepsy.Semantic proximity Read ↗

PRRT2-positive self-limited infantile epilepsy: Initial seizure characteristics and response to sodium channel blockers.Semantic proximity Read ↗

Tuberous Sclerosis Complex: Early Screening and Infant Outcome in NICU.Semantic proximity Read ↗

mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticusSemantic proximity Read ↗

[Contribution of the Ibero-American Academy of Neuropediatrics to the knowledge of self-limited epilepsy in infants].Semantic proximity Read ↗

Management of epilepsy in tuberous sclerosis complexSemantic proximity Read ↗

Compassionate use of everolimus for refractory epilepsy in a patient with MTOR mosaic mutation.Semantic proximity Read ↗

Multi‐disciplinary team approach for pediatric hemimegalencephaly: Insights from a single institutional case seriesSemantic proximity Read ↗

mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticusSemantic proximity Read ↗

Emergence of lingual dystonia and strabismus in early-onset SCN8A self-limiting familial infantile epilepsy.Semantic proximity Read ↗

Familial idiopathic West syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.