Article
Joint Analysis of Long and Short Reads Enables Accurate Estimates of Microbiome Complexity.
Cell systems - 22 Aug 2018
Bankevich Anton, Pevzner Pavel A
Abstract excerpt
Reduced microbiome diversity has been linked to several diseases. However, estimating the diversity of bacterial communities-the number and the total length of distinct genomes within a metagenome-remains an open problem in microbial ecology. Here, we describe an algorithm for estimating the microbial diversity in a metagenomic sample based on a joint analysis of short and long reads. Unlike previous approaches,...
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