Phenylalanine hydroxylase: A biomarker of disease susceptibility in Parkinson's disease and Amyotrophic lateral sclerosis.

doi:10.1016/j.mehy.2018.06.018

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Article

Phenylalanine hydroxylase: A biomarker of disease susceptibility in Parkinson's disease and Amyotrophic lateral sclerosis.

Medical hypotheses - 1 Sept 2018

Steventon Glyn B, Mitchell Stephen C

Abstract excerpt

The S-oxidation of S-carboxymethyl-l-cysteine has been reported previously to be a biomarker of disease susceptibility in Parkinson's disease and Amyotrophic lateral sclerosis. In this investigation, the original observations have been confirmed with the incidence of the poor metaboliser phenotype (no urinary recovery of S-oxide metabolites) being found to be 3.9% within healthy control population. However, 38.3%...

Topics

Amyotrophic Lateral Sclerosis
Biomarkers
Female
Genetic Predisposition to Disease
Humans
Male
Metabolomics
Models, Theoretical
Odds Ratio
Oxygen
Parkinson Disease
Phenotype
Phenylalanine Hydroxylase
Polymorphism, Genetic
Xenobiotics

Source

Open in PubMed

Identifiers

PMID: 30037610
DOI: 10.1016/j.mehy.2018.06.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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