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Article

Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion.

Medical hypotheses - 1 Sept 2018

Laskarin Gordana, Gulic Tamara, Glavan Gacanin Lana, Dominovic Marin, Haller Herman, Rukavina Daniel

Abstract excerpt

We hypothesize that progesterone causes tolerogenic maturation of myeloid dendritic cells (DCs) in human decidua of threatened miscarriage or missed abortion characterized by a distinct phenotype and cytokine production, including reduction of the main NK cell proliferation and cytotoxic factor interleukin (IL)-15. During DC/NK cell interaction, progesterone-shaped DCs cannot efficiently multiply or equip NK...

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Identifiers

PMID: 30037607
DOI: 10.1016/j.mehy.2018.04.008

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