Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

Abstract excerpt

Abdominal pain and abnormal bowel habits represent major symptoms for irritable bowel syndrome (IBS) patients that are not adequately managed. Although the etiology of IBS is not completely understood, many of the functions of the gastrointestinal (GI) tract are regulated by the enteric nervous system (ENS). Inflammation or stress-induced expression of growth factors or cytokines may lead to hyperinnervation of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Congenital gastrointestinal and neural anomalies
• Share to Gastrointestinal motility and disorders
• Share to Helicobacter pylori-related gastroenterology studies