LIMK2 acts as an oncogene in bladder cancer and its functional SNP in the microRNA-135a binding site affects bladder cancer risk.

doi:10.1002/ijc.31757

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Article

LIMK2 acts as an oncogene in bladder cancer and its functional SNP in the microRNA-135a binding site affects bladder cancer risk.

International journal of cancer - 15 Mar 2019

Wang Wei, Yang Chenglin, Nie Haibo, Qiu Xiaofu, Zhang Lianbo, Xiao Yuansong, Zhou Wuer, Zeng Qinsong, Zhang Xiaoming, Wu Yigao, Liu Jun, Ying Min

Abstract excerpt

LIM kinases modulate multiple aspects of cancer development, including cell proliferation and survival. As the mechanisms of LIMK-associated tumorigenesis are still unclear, we analyzed the tumorigenic functions of LIM kinase 2 (LIMK2) in human bladder cancer (BC) and explored whether the newly identified LIMK2 3´-UTR SNP rs2073859 (G-to-A allele) is correlated with clinical features. Expression levels of LIMK2...

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PMID: 30006972
DOI: 10.1002/ijc.31757
PMCID: PMC6587996

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LIMK2

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